Introduction: Indonesia is one of the countries with the highest malaria cases spread across the entire island including Papua. Based on 2015 Annual Parasite Incidence (API) data, the number of positive malaria cases in Papua are 54.24 per 1,000 inhabitants. Plasmodium falciparum parasites that cause malaria tropica most cause death. P. falciparum transmitted through the bite of a female Anopheles mosquito attacks immature and mature erythrocytes. It caused erythrocyte hemolysis which decreased hematocrit. The importance of hematocrit testing as a simple screening test for anemia. The general objective of this research is to know the description of hematocrit in malaria tropica patients at Jayapura Regional General Hospital of, while the specific purpose is to find out the description of hematocrit based on the average level of P. falciparum infection. Methods: This study was done during May - June 2015. The research method is descriptive. The inspection method is done manually with microhematocrit. Results: The results showed from 44 samples obtained 32 patients (73%) who had low hematocrit and 12 patients (27%) who had normal hematocrit. The mean of hematocrit in patients with malaria tropica based on the level of infection were positive 1 of 8 patiens (18%), positive 2 of 7 patiens (16%), positive 3 of 14 patiens (32%), and positive 4 of 15 patiens (34%). Conclusions: The conclusion of the study is shown that more malaria tropica (P. falciparum) patients low hematocrit based on gender and level of parasite.