SARS-COV2 commonly known as COVID-19 is a disease that has become a global pandemic since the beginning of the year in 2020. Symptoms that are related to COVID-19 are fever, cough, chest pain, weakness, a nd difficulty breathing. Some cases of patients also experience mild symptoms such as diarrhea, dizziness, nausea, and vomiting. COVID-19 firstly found with pneumonia patients has never been diagnosed in China. Pneumonia or acute respiratory disease is the main disease that supports the indication of COVID-19. The treatment has been given to COVID-19 patients one of which is antibiotics and other drugs as a symptom reliever. Dexamethasone is a corticosteroid drug given to patients with an acute respiratory system. In this article, we will discuss dexamethasone for therapy COVID-19 with some reviews of studies that have been done in patients with acute respiratory systems.