Dental implant is one of the most common standard therapies to substitute the loss of the teeth. In some cases, the implant therapies outcome was not successful, since there are several causes, which can be caused by infection or the disruption in the osseointegration process. This study aims to present an evaluation of literature regarding the rule of MMP-1 Gene in Osseointegration in Dental Implant. DNA polymorphism is related to the enhancement of the MMP-1 levels that occur in the fluid surrounding the implant associated with osseointegration disruption and periodontitis. MMP-1 gene polymorphism can be identified with disruption of osseointegration, in which its presence could predict individuals who are at high risk of early implant failure.