Cancer undergoes genetic changes that lead to the proliferation of uncontrolled cells. The cancer death rate in Indonesia based on WHO Globocon 2020 data is recorded as many as 273,523,621 peoples. Changes in taste and smell can occur before treatment, with the modality of other treatments, and in cancer patients. Taste perception are mediated by taste receptor cells on the dorsal and postero-lateral surfaces of the tongue, and on the surface of the oropharynx and larynx epithelials. T2R expression has been reported in various types of cells and also in the airways, gastrointestinal tract, pancreas, heart, breast, thyroid, skin, and testicles. T2R38 bitter taste receptor have been shown to be found in PBMC. To better determine the potential contribution of T2R38 receptor in adaptive immune responses. In this narrative review, we will provide an explanation of the T2R38, its function and can be affected by cancer.