Introduction: Chronic disease has been known as a long-term disease requiring patients to adhere to continuous medication treatment. In a bid to treat and cure chronic diseases, there are patients that practices complementary and alternative treatment (CAM) without or alongside conventional medication as it is believed to have health ben- efits in treating this non-communicable disease. The purpose of this study is to review on the prevalence, types, and beliefs of CAM among Malaysians with chronic diseases. Methods: This study followed the guidelines set by the “Preferred Reporting Items guidelines for Systematic Reviews and Meta-Analysis” (PRISMA) group. Studies were identified using electronic databases that included Science Direct, Scopus, SAGE, Springer, CINAHL, MEDLINE, and Google Scholar. Results: 13 articles that met all the eligibility criteria were reviewed in this study. Among all types of chronic diseases, patients with hypertension recorded a high number of CAM usage, followed by diabetes with natural products or biological-based therapies as the most common CAM used type. Most patients with chronic dis- eases believed that CAM was effective and much safer than conventional medicine. Conclusion: CAM treatment is a common means of treatment among the Malaysian population with chronic diseases to treat their illness depending on the health problem. The patients’ belief and conviction play a vital role in their decision to employ CAM as an alternative treatment. However, it is worth noting that the literature was limited to several types of common chronic diseases among the Malaysian population.