This review aimed to investigate the factors associated with generalised fatigue among individuals with knee osteo- arthritis. An extensive literature search was performed in Cumulative Index of Nursing and Allied Health Literature, ClinicalKey, Pubmed, Scopus and Web of Science for observational studies, available in Chinese, English or Malay language, evaluating generalised fatigue and its associated factors among individuals with clinically or radiologically diagnosed knee OA from inception up to November 2020. Five studies met the inclusion criteria and their method- ological quality was appraised using the National Heart, Lung and Blood Institute quality appraisal tool. Although high quality studies reported the comorbidities, higher mental tasks, lower physical activity levels and physical func- tion associated with fatigue, conflicting evidence indicated poor sleep quality, depression and pain associated with fatigue. The limited factors identified for generalised fatigue among individuals with knee OA thus warrant future research.