Introduction: Early warning systems (EWS) are most effective method to monitor patients’ vital signs and comply with the recommended escalation of care procedures once an emergency is recognized. The researchers noted that there were incidences of 185 (7.03%) of life-threatening medical emergencies in the inpatient room, which is either cardiac arrest or respiratory arrest cases in the Awal Bros Hospital in the year 2018. This study was to determine the relationship between nurses’ work motivation and compliance in conducting documentation of observations accord- ing to the Early Warning Score (EWS) escalation. Methods: This is a quantitative study using a descriptive correlation research method with the cross-sectional approach using the chi-square. The dependent variable is compliance in carrying out the documentation of observations according to the EWS escalation. The researcher uses the research instrument in the form of an observation sheet. Results: From a total of 63 nurses, 48 respondents (76.19%) were with strong work motivation, 19 respondents (30%) complied in documenting the results of observations according to the EWS escalation. There is no correlation between nurses’ work motivation and compliance in conducting documentation of observations according to the EWS escalation at the Awal Bros Hospital Tangerang 2019 with P-value 0.736 > P 0.05. It was evident that escalation processes was related professional factors such as acceptance and support, clear instruction, inter-disciplinary collaboration and good communication. Moreover, there is no re- lationship between Nurse’s Work Motivation with the Conduct Compliance of result documentation of Observation in accordance to Escalation EWS. Conclusion: The present would help the administration of the hospital to improve the quality of care of the nurses and influence compliance or non-compliance with EWS monitoring and escalation processes. This research would aid the hospital management to conduct supervision and regular audits to find out the quality of care in the inpatient unit.