Introduction: Filariasis is a tropical disease that is very common in several regions in Indonesia and is caused by the transmission of microorganisms through mosquito bites. The causes of filariasis in Indonesia are three filarial species, namely Wucherria bancrofti, Brugaria malayi, and Brugaria timori. One of the efforts to eliminate filariasis in Indonesia has been carried out through the provision of preventive mass drugs administration (MDA) in endemic districts / cities since 2013. Treatment is carried out once a year for five consecutive years. MDA has entered its fifth year in Kodi Balaghar District, Southwest Sumba Regency, East Nusa Tenggara (NTT). The research objective was to evaluate knowledge, behavior change and environmental changes in the community after the implementation of the MDA program for 5 years. Methods: In-depth interviews were conducted with 10 informants (Public health center nurse, program holder, head of Public health center, and head of Malando village and head of Kahale village and community members). The factors studied were public knowledge, daily behavior and control of the living en- vironment as awareness efforts to prevent filariasis. Results: The results of the study are summarized in 3 categories; increased knowledge and adherence to taking medication, found no change in daily life behavior, no change in the environment. It is feared that filariasis cases will increase after 2020 because the elimination program is not followed by changes in community behavior and also changes in the environment for filariasis prevention. Conclusion: The success of filariasis elimination is strongly influenced by community participation in the form of attitudes and con- crete actions against filariasis.