Introduction: Leprosy is a chronic infectious neural and skin disease caused by Mycobaterium leprae (M.leprae). Household contacts of leprosy are at risk for M. leprae infection and subclinical leprosy. Vitamin D is known for its affect to immune system and many studies have showed that polymorphism of vitamin D receptor gene, such as FokI, is contribute to clinical presentation and susceptibility for leprosy. The purpose of this study is to know the distribu- tion of FokI VDR polymorphism in leprosy household contacts. Methods: This is observational study conducted in Leprosy Division, Dermatology and Venereology Department, Haji Adam Malik General Hospital and Dr. Pirngadi General Hospital in Medan, also in several primary healthcare centers in North Sumatera. The inclusion criteria for household contacts are living with multibacillary leprosy patient, aged more than 15 years old, have not diagnosed with leprosy, agree to take part in the study. We recruited, interviewed, examined, and got their blood taken from 95 of leprosy household contacts. The blood sample then further examined to detect FokI VDR gene polymorphism. The collected data were tabulated. Results: Our study showed that most of leprosy household contacts have genotype Ff (53.7%) with allele F (59.5%) and female (63.2%), within productive age (30.5%) with education level of high school (35.8%), and unemployed (30.5%). Conclusion: Household contacts of leprosy patients are at risk of leprosy and can contribute to ongoing transmission. The most of FokI VDR gene polymorphism of leprosy household contacts were genotype Ff with allele F.