Introduction: Stress plays an important role in COVID-19 patients. Sleep disturbances were associated with anxiety, depression, and suicidal behavior. Proper treatment for sleep disorders is important to reduce the symptoms of psy- chiatric disorders and suicide. This study aims to determine whether there is a correlation between stress, anxiety, and depression on sleep quality of Covid-19 patients treated in isolation wards. Methods: A cross-sectional study design was conducted between July 2020 to November 2020. Subjects for this study were 54 respondents who met the inclusion criteria. The rest of the sample were excluded based on Exclusion criteria. Hospital Anxiety and Depression Scale-14, Perceived Stress Scale-10, and Pittsburgh Sleep Quality Index was used, all of the instruments were validated in the Indonesian version. The SPSS version 25 was applied for descriptive and bivariate Pearson cor- relation analysis. Results: The study showed that the average age was 38 years old, male is to female ratio showed that women were more affected than men (n=28; 51.9%), married status (n=37; 68.5%), and highly educated (n=29; 53.7%). There are correlation between stress (r=0.399; p-value=0.003), anxiety (r=0.375; p-value=0.005) and de- pression (r=0.374; p-value=0.005) with the sleep quality in patient with COVID-19. Conclusion: There are several mental disorders due to Covid-19 outbreak, but the main thing was related to stress, anxiety, and depression. All these were related to the quality of sleep of Covid-19 patients in isolation wards.