Introduction: Nurses are at the forefront and face serious risks and even face death, while treating Coronavirus pa- tients. The aim of this review is to evaluate the effect of experience of the nurses in providing care for Coronavirus patients. Methods: This is a systematic review, and numerous database were used in the article search using relevant keywords. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) flow diagram was used in selecting a total of 431 articles. Results: The 5 articles with records of encounters of medical attendants that focus on Coronavirus patients, namely in the form of psychological experiences, physical experiences, challenges in dealing with COVID-19 patients, expectations during their duties and being responsible during their duties were analyzed. Conclusions: The experience of the nurse that focused on the COVID-19 patient include discomfort, stress and fear of being contaminated and spreading to other people, experience fatigue, and feel awkward using individual defense equipment. The job of medical attendants during the Coronavirus pandemic is vital as these officials are at the bleeding edge of this pandemic.