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Prevalence of anaemia and abnormal RBC indices among T2DM patients during HbA1c measurement in Hospital Kuala Lumpur
Faridatul Husna Abdul Rahim1, Intan Nureslyna Samsudin2, Subashini C. Thambiah3, Normaizuwana Mohamed Mokhtar4.
Introduction: Anaemia in subjects with T2DM is not an infrequent finding. HbA1c, a biomarker of choice for glycae- mic control is altered by anaemia and abnormal red blood cell (RBC) indices. Hence, this study’s main objective is to determine the prevalence of anaemia and abnormal RBC indices among type 2 diabetes mellitus (T2DM) subjects who had HbA1c measurement performed in Hospital Kuala Lumpur (HKL). Method: A retrospective study of 305 subjects with concurrent HbA1c and FBC performed in Pathology Laboratory, HKL from January 2017 to December 2017. The demographic and laboratory parameters of the subjects (total Hb, MCV, MCH, MCHC, HbA1c, iron, fer- ritin, folate, B12) were attained from the laboratory information system (LIS). Results: A total of 113 (37%) subjects had anaemia, whilst 131 (43%) had abnormal RBC indices. The anaemia was mostly mild (n=70, 61.9%) and nor- mocytic normochromic (n=63, 55.8%). The median HbA1c for the anaemia group was lower (HbA1c=7.52%) com- pared to the non-anaemia group (HbA1c=8.3%) (p=0.03). The median HbA1c was significantly higher in those with microcytic hypochromic anaemia (HbA1c=7.9%) compared to normocytic normochromic anaemia (HbA1c=7.2%) (p=0.025). Conclusion: The prevalence of anaemia among T2DM subjects was 37% with the majority being mild and normocytic normochromic. HbA1c measurement is affected by anaemia and hence, whenever possible, HbA1c results should be reviewed together with the FBC results.
Affiliation:
- Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur & Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan , Malaysia
- Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan , Malaysia
- Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan , Malaysia
- Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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