Introduction: The Basic Health Research show that the number of female smokers aged over 15 years has increased between 2007-2013. Similarly in 2018, the number of female smokers in Indonesia was 4.8%, and in Palu City, there were 583 female smokers. Women smoking are 25% more at risk of some health challenges than male smokers. Based on these data we consider that smoking behavior among woman needs attention. The purpose of this study was to determine the factors related to smoking behavior among women in Palu City, Indonesia. Methods: This is a quantitative research with a cross sectional design. The technique employed was simple random sampling in which a total of 80 female smokers were selected. The data analysis was carried out using the Chi-square test with a confidence level of 95%. Results: The results showed that knowledge of smoking, (p = 0.001), peer influence (p = 0.003), early age of smoking (p = 0.010), and work status (p = 0.013), were factors associated with smoking behavior among these women. Conclusion: The conclusion is that factors related to smoking behavior include knowledge of smoking, peer influence, early age of smoking and employment status. In recommendation, there is need for women smoking to seek information about the effects of smoking especially those directed at their gender. Furthermore, it is important that health workers increase the frequency of health education as well as health promotion about the dangers of smoking to the public.