Introduction: The habit of smoking is common among Indonesian adults, teenagers, and even children. This re- search, therefore, aims to develop a non-smoking regional policy to protect children in Palu City, Indonesia. Meth- ods: Data were systematically obtained from variousonline literature reviews, including reports, journals, and books from the last ten years. The journals were mostly from scholars, while the article was screened according to the research objectives. Research that is included in the systematic discussion not completely abstracted for inclusion in this paper is issued for the inclusion of selected study details in tabular format. Results: The result showed that the use of a non-smoking regional policy is effective in preventing children smoking habits. The bureaucratic structure has been adequately implemented, however, there are lots of errors associated with the communication, disposi- tion, and resources used due to differences of opinion among policymakers, lack of human resources, and the poor commitment of stakeholders. All literature was selected and screened from scholars. Conclusion: In conclusion, a non-smoking regional policy is effective in preventing children smoking habits.