Introduction: Host Modulation Therapy is a treatment that promotes tissue repair by suppressing the host’s inflammatory response and increasing tissue repair. The purpose of this research is to provide a focused study of periodontal regeneration using Omega-3 as an HMT. Methods: The Pubmed and Cochrane databases were searched for randomized control clinical trials published within the last ten years using the following criteria: [(Periodontitis OR Periodontal Disease) AND (Omega-3) AND (Bleeding on Probing OR Pocket Depth)]. The values of Bleeding on Probing and Pocket Depth are used to assess the outcome. Only five studies out of 34 were found to meet the criteria. In four of the five studies involved, the results showed a significant reduction in Bleeding on Probing and Pocket Depth. Conclusion: Omega-3 fatty acids have a positive effect on periodontal wound healing by reducing Bleeding on Probing and Pocket Depth.