Managing chronic wound requires multimodality approach for excellent healing result. This report concentrates on tissue proliferation phase of wound healing, observing the effect of topical bioactive solution onto chronic ulcers with poor healing potential. We report a case of 36-year-old male with underlying multiple chronic co-morbidities, presented with infected chronic right diabetic foot ulcer with osteomyelitis in sepsis. He underwent multiple wound debridements and ray amputation of right fifth toe. As tissue culture grew Pseudomonas aeruginosa, IV Ceftazidime was commenced along with daily wound dressing. His poor diabetic skin condition hindered autologous skin graft harvest, thus topical liquid bioactive factors solution (CelltiSS®) was applied onto exposed tendon and bone to expedite wound healing process. Granulation tissues rapidly grew covering these bare areas and deep pocket reduced within a week. This new modern dressing technology advancement is very beneficial in treating chronic ulcers with poor healing potential as it expedites the tissue proliferation phase.