Introduction: Patients infected with covid-19 coronavirus and even influenza can die because of an overreaction of the immune system called cytokine storms. Previous research has said that turmeric (curcumin) has the ability to suppress viral infection condition where cytokine increase and continuing by increased of cytokine storm. This condition showed that curcumin potentially to using for healing Ebola patients. Curcumin seems to have very low bioavailability on our human body. In order to increase absorption, nanocurcumin which has smaller particle sub- strate was used. Our previous research has said that nanocurcumin increase mitochondrial biogenesis in skeletal muscles. This study aims to look at the effect of nanocurcumin administration on Il-6 and TNF-α which increase on high intensity endurance exercise. Methods: Wistar rats 10 weeks old used on this experiment and entered into non-exercise and exercise groups. Furthermore, every group divided with control and nanocurcumin. Curcumin doses was one hundred mg/ kilogram/day peroral on both groups for 28 days to known effect of nanocurcumin itself and nanocurcumin together with exercise. Two hours swimming exercise per-day used to determine effect of endur- ance training. Western blotting (WB) was used to detect of proteins expression IL-6 and TNF-α. Results: Compared to non-exercise group, exercise group showed enhance IL-6 and TNF-α protein expression and interested that nanocur- cumin significant abolish this effect. Conclusion: Taken together, these results suggest that nanocurcumin treatment ability decreased inflammation involved on endurance training induced cytokine storm and potentially to be one of candidate drugs to decrease cytokine storm condition.