Introduction: Gotu kola (Centella Asiatica) and exercise have shown an increase in cognitive function. However, the effect of the combination on superoxide dismutase and quality of life in humans is not yet known. The purpose of this study was to determine the effect of Centella Asiatica and aerobic exercise on memory, superoxide dismutase (SOD), and quality of life (QoL) in women with dementia. Methods: This study used a randomized, double-blind, placebo-controlled trial that lasted 24 weeks in a nursing home. The Mini-Mental State Examination is used to screen for dementia. SOD was determined using ELISA, memory was assessed using a visual memory questionnaire, and quality of life was measured using the WHO-QoL questionnaire. The study involved 62 women with dementia rang- ing in age from 61 to 89 years. Centella Asiatica is given as much as 500 mg/day. Aerobic exercise was performed for 45 minutes 3x a week, and a combination of two interventions and one group as a control group with placebo pills. Results: Centella Asiatica helped improve SOD (P=0.009) and memory (p=0.001) in women with dementia. Meanwhile, aerobic activity significantly improved memory (p<0.001), QoL-social relations (p=0.037), and QoL-en- vironment (p=0.004). In addition, the combination of Centella Asiatica and aerobic exercise significantly improved SOD (p=0.031) and memory (p=0.001). Conclusion: The combination of Centella Asiatica and aerobic exercise can improve superoxide dismutase (SOD), memory, and quality of life in women with dementia, especially in the domain of social and environmental relationships. Nurses can do this in nursing care for the elderly.