Introduction: Liver is an organ composed mostly of hepatocytes. The use of immunosuppressive drugs excessively can cause damage to hepatocytes. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are two enzymes most associated with liver cell damage. Injury to hepatocytes could result in an increase of these enzymes in blood circulation. This study aimed to investigate the correlation of hepatocytes number and ALT AST levels in immunosuppressed rats with oral candidiasis after hyperbaric oxygen treatment. Methods: Fifteen male wistar rats were divided randomly into three groups: G1 (healthy group), G2 (immunosuppressed rats with oral candidiasis), and G3 (immunosuppressed rats with oral candidiasis treated with hyperbaric oxygen). The immunosuppressed condi- tion was made by giving dexamethasone 0.5 mg/day and tetracycline 1 %/day orally for 14 days. Candida albicans 0,1 cc was applied on the dorsum tongue of rats using a sterile cotton bud, given once every two days. Hyperbaric oxygen treatment 2,4 ATA was given for 5 days continuously. Liver and blood samples were collected for counting hepatocytes and serum ALT AST levels. Data were statistically analyzed by Pearson’s correlation test. Results: Sta- tistically significant difference in the number of hepatocytes (p< 0.05) was observed between G1 and G2, G2 and G3, but not between G1 and G3. Regarding ALT and AST levels, there was no significant difference between each group (p>0,05). The correlation test showed there was no significant correlation between hepatocytes number with ALT and AST levels (p>0,05). Conclusion: The decrease of hepatocytes number in immunosuppressed rats with oral candidiasis was not accompanied by changes in the function of the livers by examining the ALT and AST levels.