Introduction: Mental disablities children experienced a delayed mental development. The clinical problems in the oral cavity of mental disablilities children are periodontal disease and dental caries. The implementation of dental health education can increase the awareness of the people living in wetlands. Mental disablilities children have low intelligence levels. Therefore, the making of interactive animated videos with Makaton modification as education media is important to maintain oral health as a self-care during the Covid pandemic. The role of parents is very im- portant in the treatment of their children’s teeth by providing examples and motivation in maintaining oral health. Methods: A quasi-experiment with pretest and posttest without control design. Samples were obtained through a simple random sampling. Total of 38 parents filled the questionnaire as a pretest, then were asked to watch a Dental Health Education (DHE) animation video for moderate mental disabilities children living in wetlands on the preven- tion of dental caries during the Covid pandemic. The samples were asked to fill the same questionnaire after 20 days. Data were analyzed using the Wilcoxon statistical test. Results: The pretest showed the parent education score of 39.5% for medium, 36.8% for excellent, and 23.7% for poor. The posttest showed a score of 44.7% for excellent, 29.5% for medium, and 15.8% for poor. The result of the Wilcoxon test showed p-value = 0.000 (p < 0.05). Con- clusion: There is an effect of parent education program through Dental Health Education (DHE) video for mental disabilities children during the Covid pandemic live in wetland.