Introduction: The sharpening of bridge denture preparation skills must be obtained during the pre-clinical period of dental education, supported by the development of adequate learning media. One of the developments is using dental models made from self-cured acrylic. However, the value of the mechanical properties of self cured acrylic is still smaller than that of tooth enamel, so it is necessary to add certain materials to improve the characteristics. One of the materials that can be added is nanohydroxyapatite from bovine bone. It is very beneficial especially when it functions as a filler in the polymer matrix because it can increase the compressive strength of a material. Objec- tives: To determine the compressive strength of self-cured acrylic cylinder with the addition of nanohydroxyapatite from bovine bone. Methods: This study used an observational analytic approach with a post test only control group design. This study involved self cured acrylic as the control group, and self cured acrylic with the addition of 2%, 5%, and 8% nanohidroxyapatite as the treatment group. The data obtained was analyzed by one-way ANOVA test. Results: Based the test, it is obtained p <0.005 that means there is a the difference between the control group and the treatment group. The higher mean number of compressive strength is in the sample with addition of 8% nanohi- droxyapatite (94.85 MPa). Conclusion: There was an increase in the compressive strength of self cured acrylic with addition of nanohydroxyapatite from bovine bone as basic material for dental models in prosthodontics clinical skills learning.