Introduction: Angiogenesis plays a role in wound healing to supply oxygen and nutrients to the wound area. Cher- ry leaf extract (Muntingia calabura L.) contains flavonoid compounds that can trigger angiogenesis and help in wound healing. The study aimed to explore the effect of giving ethanol extract gel of cherry leaves on the number of blood vessels in the socket of rats after tooth extraction. Methods: 24 male rats with maxillary incisors extracted were divided into six groups, consisting of three control groups without extract and the other three groups given a cherry leaf extract gel 50%. The gel was administered twice a day on the post-extraction rat tooth sockets. The tooth socket tissue sampling was carried out in the control and treatment groups on the third, fifth, and seventh days after extraction, respectively. The number of blood vessels was calculated from the histological preparations of the tooth sockets stained with Hemaxtocylin-Eosin. Results: The unpaired t-test showed a significant difference between the treatment and control groups (p<0.05). Conclusion: Kersen leaf ethanol extract gel can stimulate the formation of blood vessels in the rat tooth socket after extraction.