Introduction: The process of bone recovery after tooth extraction requires the right method to overcome alveolar bone loss using bone graft implantation. Indicators of Success of Blood Vessels as transportation of nutrients and ox- ygen in the process of healing bones. Bone-derived tooth graft is one of the bone graft material containing hydroxy- apatite which is able to influence the process of forming new blood vessels. One of the ideal bone graft selection factors is graft particle size. The purpose of this study was to study the number of blood vessels in the bone healing process of Wistar rats after implantation of 20, 40, and 60 Mesh tooth graft. Methods:This research was carried out with a one shot case study. Random sample selection, as many as 27 Wistar mice made a spine in the right femur. Samples were divided into three groups: Treatment Group 1 (P1): defects filled with 20 Mesh tooth graft, Treatment Group (P2): defects filled with 40 Mesh tooth graft, and Treatment Group 3 (P3): defects filled with 60 Mesh tooth graft. After 14 days the mice were sacrificed then the samples were made histological preparations for the calcula- tion of blood counts. Results: Homogeneity and normality tests show that the data are homogeneous and normally distributed. One Way ANOVA test to compare each group (α = 0.05) and the results obtained indicate a significance value of 0,000. Conclusion: Based on this study it can be concluded that there are differences in the amount of blood in each group that has different particle sizes.