Introduction: PECAM-1 (Platelet Endothelial Adhesion Molecule-1) is a cell adhesion molecule and mediator of interaction, both between leukocytes and endothelial as well as endothelial and endothelial. PECAM-1 plays an important role in the process of wound healing angiogenesis. PECAM-1 antibodies characterize the neoangiogenic response of wounds in rats performed by immunostaining PECAM-1 endothelial cell markers in wounds during the healing process. Ciplukan fruit extract gel containing lupeol active compounds can increase wound closure pro- motion by inducing granulation tissue and increasing re-epithelialization, β-sitosterol has an effect on angiogenesis by influencing endothelial cells. The purpose of this study was to determine whether there were differences in the administration of ciplukan (Physalis angulata L.) Gel Gel extract with triamcinolone acetonide on PECAM-1 ex- pression and wound closure in wound healing of white rat mucous traumatic ulcer traumatic ulcer. Methods: The method used was true experimental randomized posttest only control group design in vivo, this study was divided into 9 groups with 3 time series, namely the 2nd, 6th and 12th days of the control group, Physalis and Triamcinolone after the formation of traumatic ulcers. The next stage is the removal of traumatic ulcer tissue, HE and IHK staining, then PECAM-1 expression is observed using a light microscope equipped with a digital camera and wound closure is observed daily and documented. Results: The results of the independent t-test showed significant differences in the physalis and triamcinolone groups on the 2nd, 6th and 12th days. Correlation test results in the physalis group showed that the longer the treatment could increase PECAM-1 expression and wound closure, the triamcinolone group the longer the treatment could reduce PECAM-1 expression. Conclusion: There are differences in the adminis- tration of ciplukan fruit extract gel with triamcinolone acetonide on the expression of PECAM-1 and wound closure in the healing process of traumatic mucosal traumatic ulcer wounds of white rats.