Saliva is oral biofluid that contain a lot of markers which can use to detect some disease, either systemic or oral diseases. The purpose of this review is to find out salivary biomarkers which can be detected in dental caries. Bio- markers for caries diagnosis in this review can be classified by the number of the specific bacteria for dental caries, innate host defense protein and peptides; and functional properties of saliva. Streptococcus mutans, Streptococcus sobrinus, and Lactobacilli were found to be increased in individuals who have caries compared to control. In ad- dition to the number of bacteria, innate host defense proteins and peptides in saliva used as biomarkers for dental caries, includes agglutinins, amylases, lysozymes, lactoferrin, and glycoproteins. The functional properties of saliva also can be used as markers in caries, with parameter include flow rate, pH, buffer capacity, sugar clearance rate of saliva. It can be concluded that saliva is a non-invasive media which has variety of biomarkers that can be used as a diagnosis of dental caries.