Chronic Periodontitis is mainly caused by Porphyromonas gingivalis, with scaling root planing as its first-line treatment. It requires coolant for several purposes but increases the chances of bacterial aerosol production and cross-contamination. Cinnamaldehyde in cinnamon’s bark shows beneficial properties, as an anti-inflammatory and anti-bacterial in periodontal pocket. Also, it could reduce the bacterial colony-forming unit (CFU) in dental aerosol. This review was conducted by collecting studies through 2011 - 2021 from databases including “Google Scholar”, “PubMed”, “SpringerLink”, and “ScienceDirect”. Cinnamaldehyde has an anti-bacterial effect by damaging the bac- terial cell permeability and membrane integrity. Besides, Cinnamaldehyde also shows an anti-inflammatory effect by inhibiting the pro-inflammatory cytokines in chronic periodontitis such as tumour necrosis factor alpha (TNF-α), interleukin (IL) -6, nuclear factor-κappab (NF-kB). Cinnamaldehyde promotes the maturation and differentiation of osteoblast by enhancing the expression of runt-related transcription factor 2 (runx2), osteocalcin (OCN), and colla- gen 1 alpha 1 (col1a1). Discussion: “Red complex” pathogens in chronic periodontitis produces pro-inflammato- ry cytokines and periodontal destruction. Bacteria produced lipopolysaccharide induced polymorphonuclear and Monocytes migrations, which secrete pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) therefore upregulate receptor activator of nuclear factor-kappab (RANKL), leads to periodontal destruction. Cinnamaldehyde reduces IL-6 and TNF-α, which plays a role in tissue destruction, fibroblast apoptosis, and bone resorption. Cinnamaldehyde also inhibits NF-kB transcriptional activity, effective in inhibiting osteoclast formation. Cinnamaldehyde enhances runx2, ocn, and col1a1 production, leads to osteoblast differentiation and maturation in bone regeneration. Using Cin- namaldehyde as an ultrasonic scalers coolant shows decreasing score of CFU in dental aerosol due to its anti-bacte- rial effect. Cinnamaldehyde as ultrasonic scalers coolant has the potential to reduce bacteria aerosol contamination and enhance chronic periodontitis healing.