Following World Health Organization (WHO) recommendations, most of the dental clinics significantly reduced their activities during pandemic COVID-19. The elective dental treatments were postponed with mainly emergency and urgent care remaining, such as tooth extraction. Topical medicine that can help to rapidly heal the wound after tooth extraction is necessary to minimalize dental visit. Recently, alternative medicine has gained popularity due to its herbal properties with no adverse effects. Amongs them, green coffee bean extract is receiving greater attention due to its antibacterial, antioxidant, anticancer, and anti-inflammation activity. Thus, in this study explain that the role of Chlorogenic Acid (CGA) from green coffee bean extract (Coffea canephora) as topical medicine for post tooth extraction. This is a systematic review from Medline (PubMed) and Google Scholar databases, from 2011 until 2021. Green robusta coffee beans extract phytochemical screening showed high amounts of alkaloid, flavonoid, and chlorogenic acids (CGA), which can increase the amount of osteoblast, fibroblast, and inflammatory cells which had potential effect to promote post tooth extraction wound healing. Antioxidant from CGA have the ability to decrease the amount of free radical (ROS) production. CGA from green coffee robusta is recommended as topical medicine for post tooth extraction treatment.