Recurrent Intraoral Herpes (RIH) is a common manifestation of herpes simplex virus (HSV) reactivation, in the im- munocompetent host occurs chiefly on the keratinized mucosa of the hard palatal mucosa, attached gingiva, and dorsum of the tongue. Reactivation of Herpes Simplex Virus (HSV) are common due to physical and psychological stress, anxiety, ultraviolet radiation, trauma, and menstruation. Birt-Hogg-Dubé syndrome is a hereditary condition associated with multiple benign skin tumors, lung cysts, and an increased risk of kidney lesions that can contribute to patient anxiety levels. The aim is to present the rational management of recurrent intraoral herpes on patient with overall self-physical condition anxiety caused by Birt Hogg-Dubé syndrome. A 57-year-old female Birt-Hogg-Dubé syndrome patient came to Dental and Oral Hospital, Faculty of Dentistry, Universitas Indonesia, complains of se- vere pain on her mouth after having her upper tooth extracted 6 days ago. Intra oral examination shows multiple irregular ulcers on her palate and single irregular ulcer on lateral of the tongue. There is no evidence of new lesions during the past 72 hours. She is having a general anxiety upon any of her physical condition ever since she has been diagnosed with the syndrome. Definitive diagnosis established were Recurrent Intraoral Herpes (RIH) based on the titer antibody of HSV 1 and traumatic ulcer due to iatrogenic trauma during tooth extraction. A comprehensive treat- ment includes reassurance regarding the patient anxiety about relation of her condition with malignancy condition along with pharmacological therapy with chlorhexidine gluconate 0,2 % mouth rinse, aloclair gel and multivitamin with addition of self-suggestion stress management as the non-pharmacological therapy. There is no recurrence on 5-months follow up. A thorough examination and customized comprehensive treatment are very important in the management of RIH on patient with conditions that caused high levels of anxiety.