Coronavirus disease 2019 known as COVID-19 is a new disease caused by severe acute respiratory syndrome coro- navirus 2 (SARS-CoV-2). Even though many oral lesions related to COVID-19 have been reported, there is still no consensus of which are actually the oral manifestations, including oral outcomes in COVID-19 survivor. This case report aims to discuss the challenges in diagnosing unspecified oral lesions that occurred post COVID-19 infection. A 46-year-old male came to Oral Medicine Clinic of Universitas Indonesia Dental Hospital with a complaint of mouth soreness for four days, preceded by fever prior to his visit. The patient had histories of COVID-19 infection, in five and four months earlier, which followed by neuropathy as a neurological sequelae of COVID-19 and continuously consumed concoction medication for 2 months. Extra oral examination showed desquamation, brownish crusts and mild bleeding on lips. Intra oral examination revealed multiple, shallow, round ulcerations, surrounded by erythema area on several locations of the mouth, that mimicking herpetiform viral ulceration. The serological test for HSV 1 and 2 was performed to defined HSV involvement, which showed negative result. Diagnosis was established as unspecified oral lesions related to post-COVID infection. The patient was prescribed with chlorhexidine gluconate 0.2% mouthwash, Vaseline album and multivitamin plus minerals. In the management of challenging oral lesions with unspecified characteristic in post-COVID patient, all health professional, including dentist, should perform a comprehensive examination and treatment approach.