Oral lichen planus (OLP) is a chronic inflammatory condition of oral mucosa with a high prevalence in females. Factors such as psychological stress, and several other conditions such as malnutrition, and anemia can serve as triggers of OLP occurrence, but the exact cause is controversial. This case report aims to discuss the role of stress as triggers for OLP in anemic patients. A 64-year-old female patient came to Universitas Indonesia Dental Hospital, with a complaint of bumps on inner part of her right and left cheeks for 1 month. The patient has already gargled with po- vidone iodine and chlorhexidine gluconate but there were no changes. She admitted of feeling tired due to domestic conditions. Intraoral examination revealed some diffuse white striaes, located bilaterally on the buccal mucosa of 14-17 and 25-27, with ulceration and erosion of the buccal gingiva 16 along with areas of gingival desquamation. The screening using DASS 42 indicates the presence of anxiety and stress on a moderate scale, while the results of routine blood tests showed anemia. The patient was given a dexamethasone rinse twice a day and multivitamins con- taining antioxidants and minerals for 10 days. She was also educated to manage her stress and to increase nutritional intake to correct anemia. The patient was regularly monitored which showed lesion improvement and reduced pain complaints. Establishing the possible predisposing factors in the management of Oral Lichen Planus is essential in order to gain optimal treatment results.