Oral cavity is the entrance of various antigens (Ag), including dental restoration. Dental restoration is classified into direct (amalgam) and indirect restoration (ceramic crown). Mucosal reactions of the oral cavity that often occur due to amalgam dental restoration is Lichenoid Drug Reaction (LDR). LDR causes a long term-pain, which has a signif- icant impact on the quality of life. Discusses etiopathogenesis and management case that cause LDR and expects a good future prospect of dental restoration. Cases : The first case, 48-year-old woman came with sprue since 6 months ago. It has been treated but does not show any improvement. On clinical examination, there was amalgam in right mandibular first molar. The second case, women, aged 56 years old with painful sensation complaints on the left cheek since 4 years ago. Patients used ceramic crown at left mandibular first molar. Management : Management of cases, biopsies are performed. The histopathologic feature was chronic inflammatory cells. The patients was given a corticosteroid drug and Benzydamine HCl mouthwash. The next treatment planning for replacement of composite materials as dental restorations and ceramic crown will be replaced with denture of acrylic material. Conclusions : To improve the quality of life of patients with LDR, it is hoped that the role of the oral medicine specialist as a clini- cian for complaints related to dental restoration material is expected.