It is crucial to keep a sufficient amount of safe, unexpired and necessary floor stock medications in the Emergency and Trauma Department (ETD) at all times to deliver timely patient care. However, medication stockpiling or inappropriate accumulation of medication is common and has been shown to cause medication wastage, ineffective treatment or toxic effects due to the medication’s expiration. In Port Dickson Hospital, the ETD contributed to 26.1% and 67.7% of floor stock medications with excessive quantity out of all units and wards in 2018 and 2019, respectively. Hence, this quality improvement study aimed to achieve a 50% reduction in floor stock medications with excessive quantity in the ETD of Port Dickson Hospital from the baseline of 11.2% over an approximately one-year duration. A self-administered survey form was distributed among 40 doctors, pharmacy staff, staff nurses and medical assistants to identify the contributing factors. The main contributing factors identified were inefficient management and supervision, non-adherence to standard operating procedures (SOPs) and improper stock management in the ETD. The remedial measures undertaken to solve the problems included appointing an emergency physician, a chief nurse, a chief medical assistant and an in-patient pharmacist to be responsible for stock issues; revising the indent form; reorganising the medication storage area; providing medication storage conditions by the pharmacy department to the ETD staff; reminding medical assistants to return excessive or near expiry medications monthly; reinforcing SOPs on documentation and counter-checking. After five study cycles, the interventions reduced the percentage of floor stock medications with excessive quantity from 11.2% to 1%. Efforts have been made to replicate the remedial measures used in this study in other units and wards, and continuous monitoring is necessary to ensure the effects can be sustained in the long term.