Marine biotoxins are naturally occurring chemicals produced by certain types of toxic algae. Exposure to marine biotoxins can occur through consumption of toxin-contaminated seafood, direct contact by swimming or breathing in aerosolised toxins in water droplets. Symptoms of food poisoning can vary depending on the types of toxins ingested. Symptoms may vary from severe gastrointestinal intoxication symptoms such as diarrhoea, nausea, vomiting, and abdominal cramps to neurological disorders such as ataxia, dizziness, partial paralysis, and respiratory distress. In Malaysia, paralytic shellfish poisoning and tetradotoxin poisoning are the two most frequently reported cases of marine biotoxins poisoning. Poisoning cases are more often reported in Sabah and Sarawak than in the Peninsular Malaysia. This paper presents information on marine biotoxins in general as well as cases related to biotoxins poisoning that have been reported particularly in Malaysia. This paper also highlights biotoxins monitoring programs, analytical capabilities in the country as well as reference safety standards for biotoxins in shellfish.