SirehMAX TM is a product that has shown positive impact on prevention against bacterial infection in fish, in addition to the enhancement of growth performance. In this study, the effect of SirehMAX TM, a plant-based product from Piper betle leaves on growth performance and survival of sea bass (Lates calcarifer) larvae against vibriosis were investigated. Cytotoxic bioassay of SirehMAX TM was assessed using rotifer. The LC50 value of rotifer was observed as 10 mg/L. After optimization, rotifer used in the study were enriched in 10 mg/L of herbal product for 3 h in a well aerated container and given to the fish twice daily. Survival and growth rate of the seabass larvae were monitored and compared to control. Results indicated that the addition of SirehMAXTM increased growth of seabass larvae at 47%. The survival result indicated a slightly different of 15% but there are no significant different between the group. The result presented suggested that SirehMAXTM could be used as enrichment feed for live feed to attain higher and faster growth during larval development, thus providing a new technology for mass production of fry and fingerlings.