Adoption of e-business is extremely a dominant strategy to survive, stay competitive and grow for businesses. However, empirical studies one-businessadoption in recent years have been scarce. The purpose of this paper is to review the papersystematically to explore determinants of e-business adoption inSmall and Medium Enterprises (SMEs) of developing countries. E-business has substantial potential for SMEs in developed and developing countries alike.Nevertheless,to accelerate the shiftfrom traditional businessto e-business in developing countries facedmany challenges inpractical useand the issueshave not been adequately addressed (Mkansi.M, 2020). In the scarcity of the extant literature, the direction of future work outlined. Guided by PRISMAtechnique (Moher et al., 2009), three online databases, Scopus, Web of Science and Springer Link Journal were deployed, resulting in 27 articles wereincluded inthe literature review andhave beenidentified anddiversifiedinto various factors whichrelatedto the frequency ofoccurrence in manyresearches which apply technology-organization-environment (TOE) framework (Tornatzky and Fleisher, 1990). Further analysis of the studies under TOEframework revealed four significantthemes: (1) Technological Context, (2) Environmental Context, (3) Organizational Context, and (4) Individual Context.The themes are combined into a proposed e-business adoption framework and recommendations are reconciled according to the proposed framework. Thispaper incorporates the insights of the determinants of e-business adoption in SMEs, it suggested pertinent issues for future research endeavors and serve as aportrait for more SMEs entrepreneurs in developing countries to adopt e-business to sustain, remain competitive and bloom in current covid-19 pandemicandhereafter.