The widespread expansion of dengue is alarming. The challenges of vector control strategies warrants the implementation of alternative assessments to curb its invasion. This review summarizes the contemporary knowledge on the credible use of human antibody response towards mosquito salivary protein as predictive markers for dengue infection. The literature was sourced from electronic databases such as Scopus, PubMed, Springer Link, Wiley On- line Library and Science Direct. Keywords such as “salivary proteins”, “biomarker”, “dengue” “antibody response” were utilised. The evaluation of antibody reaction towards salivary peptides in mosquitoes is a practical immuno-ep- idemiological method that could be further explored to heighten the diagnostic monitoring of dengue transmission.