Recently, researchers studied the increase in environmental contamination, particularly the increase in abnormalities and blood levels in aquatic creatures. Microplastics (<5mm) are formed as a result of the decomposition of macroplastics and mesoplastics in water. Blood components and blood levels used to determine the condition or health state of dumbo catfish (Claries gariepinus) by counting the number might change in response to environmental factors. A completely randomized design (CRD) with one factor and three treatment levels was used in this study. The results showed the rearing time increased from 0 to 30 days and that the doses of commercial fish feed and microplastic varied. The results showed the highest erythrocyte level of 2.78(x106) cell/mm3 in 15 days of rearing time by adding mixed commercial feed and microplastics of 15%. While the highest level of monocytes and lymphocytes by mixed commercial feed and microplastics of 15% on 30 days rearing time were 20.14x103) cell/mm3 and 89.61(x103) cell/mm3, respectively. Meanwhile, the number of leukocytes reached highest level of 23.28(x103) cell/mm3 by adding mixed commercial feed and microplastics of 15% on 30 days of rearing time. Highest level of hemoglobin of 5.58 g/dL was achieved by adding the mixed commercial feed and microplastic of 15% and rearing time of 15 days. The amounts of erythrocyte, leucocyte, hemoglobin, and differentiall eucocyte components in blood were analyzed to determine whether fish underwent a stress reaction after consuming microplastic. The four parameter values did not show any signs of stress in the fish.