This study aims to evaluate the tribological performance of various commercially available perfluoropolyether (PFPE)-based greases in order to assess their potential application in automotive bearings. The composition and specification of the greases are taken into consideration for the analysis. The thermal oxidative stability of the selected grease is determined through oxidative thermo-gravimetric analysis test. Subsequently, the greases are evaluated for their frictional and wear behaviour using a ball-on-disk tribometer. To assess the wear condition of the ball and disk, a digital microscope with Amscope software is employed. The study reveals a scarcity of PFPE lubricant applications in the automotive sector. Among the greases tested, GPL 205 exhibits the highest thermal oxidative stability, characterized by the highest onset temperature of 321°C. Conversely, GPL 215 demonstrates superior friction reduction and anti-wear properties.