Spacecraft have been dispatched to Mars as part of human missions aimed at exploring new frontiers, driven by the observed similarities between the red planet and Earth. This endeavour has facilitated the development of construction materials suitable for human settlements on Mars. To determine the optimal properties for constructing habitable infrastructure for humans on Mars, research efforts have led to the discovery of Martian concrete, composed of sulphur and Martian simulants that had been produced without water, which is in scarce supply on Mars. By utilising egolith available near the construction site, structures can be built efficiently and rapidly, supporting the establishment of sustainable human habitats on Mars. Several studies have been conducted to address the challenges associated with identifying the ideal proportions of Martian concrete. Given the extreme and harsh conditions on Mars, there is a growing interest in understanding how the properties of Martian concrete can mitigate and alleviate fatigue resulting from the planet’s daily conditions, such as temperature variations and dusty storms, which impose cyclic loading on structures. Therefore, it is crucial to investigate the fatigue characteristicsof Martian concrete. By evaluating the fatigue properties of Martian concrete, considering the selected appropriate mix design ratios, this study aims to contribute to understanding the impact of Martian conditions on construction practices. Ultimately, the findings of this study can assist future researchers in comprehending the effects of the Martian environment on the planet’s construction process.