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Hepatitis C: a review on current and emerging genotyping assays
Rafidah Hanim Shueb1, Nur Amalin Zahirah Mohd Amin2, Tuan Nur Akmalina Mat Jusoh3, Ahmad Adebayo Irekeola4.
Hepatitis C is a global public health concern that infects millions of people worldwide. The continual discovery of new genotypes and subtypes of hepatitis C virus (HCV) is an indication of a persistent molecular evolution of the virus. This remains a concern in the efforts towards hepatitis C elimination, as effective management of the disease is, in part, dependent on the HCV genotype responsible for the infection. Accurate HCV screening and quantification using rapid but highly sensitive and reliable methods are crucial for the diagnosis and subsequent management of HCV-related diseases. Thus, this article discusses HCV and the common methods employed for HCV detection and genotyping. While nucleotide sequencing and phylogenetic analysis of core/E1 and NS5B region are regarded as the gold standard and the most recommended method used for HCV genotyping, electrochemical sensors are being explored for their rapidity.
Affiliation:
- Universiti Sains Malaysia, Malaysia, Malaysia
- Universiti Sains Malaysia, Malaysia, Malaysia
- Universiti Sains Malaysia, Malaysia, Malaysia
- Summit University Offa, Nigeria, Nigeria
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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