Amidst the contemporary challenges, the profound impact of Covid-19 on mental health and stress levels among students in Malaysia, particularly in the context of pharmacy education, requires urgent consideration. Historically marginalized, mental health issues are gaining recognition for their critical significance. This study explores the psychological repercussions of the Covid-19 pandemic on the stress and mental well-being of Diploma in Pharmacy students at Universiti Teknologi MARA (UiTM) Cawangan Pulau Pinang. The research, encompassing 116 respondents, predominantly female (85.3%), aims to elucidate students' self-awareness of their health status. Results reveal notable instances of fatigue, sleep difficulties, and heightened stress during online learning. Specifically, 50.9% of students experience occasional stress during assignments, and 16.4% report constant stress. Despite feelings of despair among 54.3% of students, no significant gender-based differences emerge. The study emphasizes the imperative to address mental health and stress levels among pharmacy students and underscores students' awareness of their well-being. In conclusion, proactive measures and support are essential for students at UiTM Cawangan Pulau Pinang, Kampus Bertam, navigating the challenges of mental health and stress in the post-Covid era.