Introduction: This article focuses on doctors' responsibility for the Indonesian vaccination program as the Indonesian Government program in the health sector. Since the WHO declared Covid-19 a pandemic, Indonesian citizens must get a vaccine for antibodies. However, the Covid-19 vaccine as an emergency use vaccine has a Post-Immunisa- tion Adverse Event. The problem of this research is to what extend the doctor's responsibility both in civil law and criminal law for detriment due to covid-19 vaccine especially in the Indonesian legal system. Methods: This study uses normative legal research with a statutory and conceptual approach. Sources of legal materials are obtained from primary legal materials, such as statutory regulations and secondary legal materials, namely books and scien- tific journals. Results: Doctors in Covid-19 vaccination program must comply with professional standard operating procedures and ethics in. Violation of this standard will be subject to legal and ethical sanctions. A legal sanction includes civil and criminal punishment after being analysed by the disciplinary and ethics committee. Doctors are also responsible for nurses' and midwives' errors in vaccine injection as a form of delegation authority. Conclusions: Based on Indonesian regulations, vaccine practitioner is doctors, nurses and midwives. Both nurses and midwives must be under a doctor's supervision. In practice, improving antibodies through the vaccine has adverse. Conse- quently, governments and vaccine practitioners are potentially responsible in front of the law, both civil and criminal law when certain criteria are meet.