The North Tabriz and North Misho faults (NTNMF) comprise a dextral strike-slip fault system in a compressional-extensional regime of complex geometry, the displacements along the different segments of the main and subsidiary faults affect the longitudinal profiles of streams. This study presents detailed observations of longitudinal profiles that have been affected by deformation. Two domains are distinguishable along the NTNMF, as indicated by the response of the longitudinal profiles to related vertical displacements. The domain that surrounds the North Misho fault is characterised by concave longitudinal profiles and high H* values (the difference between the estimated elevation and the actual elevation of the intersection point on the profile). The domain that surrounds the North Tabriz fault is characterized by generally less concave or even slightly convex longitudinal profiles and either no knickpoint or low H* values. Sub-domains of each domain can also be recognised. The NTNMF affects the longitudinal profiles of streams by three mechanisms: (i) crushing the fault zone and lowering the base level; (ii) creating local, sometimes temporary, compressionalextensional or compressional-contractional regimes through subsidiary faults or interaction with other faults; and (iii) dividing major, probably more independent, deformational zones. This paper shows that within the study region, the stream responses to geological forces can be effectively controlled through lithostructural transitions in the tectonic regimes where flow occurs and through spatial relationships between the streams and geologic structures (such as faults, folds, fault-induced scarps, and landslides).