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The effect of tinospora crispa extracts on the contraction of isolated atrium and aorta of rats
Nor Aziyah Bakhari1, Norain Isa2.
In the present study, the cardiovascular effect ofTinospora crispa extracts on the isolated paced left atrium, spontaneously beating right atrium and the descending aorta of rats were studied. The stems of T crispa were serially extracted with petroleum ether. followed by chloroform, methanol and lastly water. The chloroform extract caused the strongest inhibition on the inotropic effect of isoprenaline (ISP) to left atrium. The inhibition curve of the was noncompetetive since the maximum of the log dose-response curve of the atrium to ISP was redused. However, none of the extracts (0.2 - 1. 0 mg/mL) significantly influenced the inotropic activity of the right atrillm to IS? All the extracts studied also non-competetively inhibited the noradrenaline (NA)-induced rat aortic strips contraction and the chloroform extract was again found to be the most potent extract. The chloroform extract was therefore fractionated and the effect ofthe fractions on the NA-induced rat aortic strips contraction was examined. CF3fraction was found to be the most active fraction and was further fractionated. The fractions were tested again on the NA-induced rat aortic strips contraction. However, all fractions showed almost the same effect 80%.
Affiliation:
- Universiti Teknologi MARA, Malaysia
- Universiti Teknologi MARA, Malaysia
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