This paper attempts to enlighten the concept of psycho-spiritual therapy approach in drug addiction rehabilitation. It was believed that a drug addict involves in drug abuse simply because he does not have a strong spiritual life, therefore, a strong spiritual life not only can prevent some one from involving in drug abuse but also can give an effective treatment to drug addicts. This paper focuses mainly on theoretical aspect of the approach; nevertheless, it is substantiated by the outcome of reliable field researches done in Pondok Remaja Inabah both in Indonesia (the centre) and Malaysia (the branch).