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Levels of Malondialdehyde-Related Immune Reactants in a Lupus Prone Mouse Strain
Yahya M.D1, Lung, C.C2, Pinnas, Yacob L3.
The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice.
Aras antibodi anti-malondialdehida (MDA) dalam mencit MRL/lpr berbeza umur telah dibandingkan dengan aras antibodi anti-DNA. Mencit ini menghasilkan antibodi anti-MDA lebih awal dan pada aras yang lebih tinggi berbanding antibodi anti-DNA. Aras kompleks imun yang mengandungi MDA juga lebih tinggi berbanding aras dalam 3 strain mencit lain. Pergabungan MDA dengan suatu protein serum bersaiz 100 kDa dikesan pada mencit berumur 3 dan 5 bulan. Kompleks imun yang mengandungi MDA dan antibodi anti-MDA mungkin merupakan satu lagi mekanisma yang terlibat dalam patogenesis penyakit lupus pada mencit strain ini.
Affiliation:
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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6 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Web of Science (SCIE - Science Citation Index Expanded) |
Impact Factor
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JCR (1.009) |
Rank |
Q4 (Multidisciplinary Sciences) |
Additional Information |
JCI (0.15) |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (1.4) |
Rank |
Q2 (Multidisciplinary) |
Additional Information |
SJR (0.251) |
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