Automatic segmentation of brain images is a challenging problem due to the complex structure of brain images, as well as to the absence of anatomy models. Brain segmentation into white matter, gray matter, and cerebral spinal fluid, is an important stage for many problems, including the studies in 3-D visualizations for disease detection and surgical planning. In this paper we present a novel fully automated framework for tissue classification of brain in MR Images that is a combination of two techniques: GLCM and SVM, each of which has been customized for the problem of brain tissue segmentation such that the results are more robust than its individual components that is demonstrated through experiments. The proposed framework has been validated on brainweb dataset of different modalities, with desirable performance in the presence of noise and bias field. To evaluate the performance of the proposed method the Kappa similarity index is computed. Our method achieves higher kappa index (91.5) compared with other methods currently in use. As an application, our method has been used for segmentation of MR images with promising results.