View Article |
Evaluation biological activities of piper sp intended for skin formulation preservative
Saidatul Husni Saidin1, Norulaiman Yusoff2, Fauziah Abdullah3, Mastura Mohtar4, Boo Kean, Ong5, Vimala, Subramaniam6, Nor Azah Mohamad Ali7, Mary, Khoo8, Nuziah Hashim9, Mohd Irman Shah Mustafar10.
Preservatives are substances added into product to prevent their premature spoilage.
Preservative helps to prolong the product’s shelf life by protecting the product from microbial
growth and oxidation process. In this study, the potential of a Piper sp. as preservative for
cosmetic products is being investigated. The exploration begins with the screening of major
phytochemical groups; flavonoid, steroid, alkaloid, saponin and triterpene. Evaluation of
biological activities exhibited the plant possessed antimicrobial property towards two strains of
Staphylococcus aureus and free radical scavenging capacity. The minimum inhibitory
concentration values (MIC) for both S. aureus ATCC 25923 and S. aureus ATCC 6538 is 2500 g/mL
and 312.5 g/mL respectively. Free radical scavenging capacity of the plant was determined
via Superoxide scavenging assay and DPPH radical scavenging assay and the capacity values
are 76.4+0.35% and 59.7+0.75% respectively. Cytotoxicity study was also carried out to determine
the safety of Piper sp. where median inhibitory concentration (IC50) value for normal kidney cell
lines (Vero) is 62.96 g/mL and normal liver cell lines (WRL-68) is 69.91g/mL. The extract of Piper
sp. was formulated as cosmetic preservative ingredient especially for topical product. The
specification of ingredient’s characteristic and performance were described based on colour,
odour, pH value as well the solubility in product formulation and stability at 4C, room
temperature and 40C.
Affiliation:
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
- Forest Research Institute Malaysia (FRIM), Malaysia
Toggle translation
Download this article (This article has been downloaded 132 time(s))
|
|
Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
|
6 |
Immediacy Index
|
0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
|
CiteScore (1.4) |
Rank |
Q3 (Engineering (all)) |
Additional Information |
SJR (0.191) |
|
|
|