The use of multimedia instructions for learning purposes has become very common due to the advances of the Internet technology. With this reason, museums around the world are utilizing such technology in order to provide richer museum learning experiences to their visitors. This paper discusses a study that investigated the relationship between multimedia instructional strategies with individual cognitive styles preferences in a museum environment. Comparison of the web-based and physical museum settings , the findings based on a pre-test post-test quasi experiment reveals that the general performances of museum visitors exposed to multimedia instructions in a web-based environment is better than in the physical environment. Further analysis on the individual cognitive styles preferences (SCSD) and the combined cognitive style (CCSD) were also discussed. The analysis also reveals that there is an interactive effect between the individual cognitive styles and the multimedia instructions in the museum learning experience.