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Protective effect of stevia rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress
Norhisham Haron1, Nuraishah Abu Hasan2, Siti Nazrina Camalxaman3, Emida Mohamed4, Azlin Sham Rambely5, Zulkhairi Amom6.
Stevia rebaudiana, a member of Asteraceae family is rich in stevioside and
total phenolic compounds. The aim of the present study was to investigate the
protective effect of Stevia rebaudiana leaf extract on human erythrocytes
against oxidative damage, in vitro. The protective effect of Stevia rebaudiana
leaf extract in erythrocytes was studied in terms of resistance to hemolysis,
lipid peroxidation and morphological changes. Stevia rebaudiana leaf extract
at different concentrations (100, 200 and 300 µg/mL) was tested in 10 mM
hydrogen peroxide (H2O2) induced oxidative stress on human erythrocytes. The
hemolysis of erythrocytes induced by H2O2 was inhibited in a dose-dependent
manner. The Stevia rebaudiana leaf extract was found to inhibit erythrocyte’s
lipid peroxidation caused by H2O2. Morphological alterations in erythrocytes
induced by H2O2 were protected by the leaf extract. In conclusion, the study
demonstrated that Stevia rebaudiana leaf extract protected erythrocytes
against oxidative damage due to its antioxidant properties.
Affiliation:
- Universiti Teknologi MARA, Malaysia
- Universiti Teknologi MARA, Malaysia
- Universiti Teknologi MARA, Malaysia
- Universiti Teknologi MARA, Malaysia
- Universiti Teknologi MARA, Malaysia
- Universiti Teknologi MARA, Malaysia
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